The NFL announced that Amazon Prime Video will be the exclusive home of Thursday Night Football beginning in the 2022 season. Amazon will distribute primetime's second most-watched show across hundreds of compatible digital devices. The NFL's original agreement with Amazon, announced as part of a larger series of media distribution deals this past March, had Amazon Prime Video hosting Thursday Night Football starting with the 2023 season.

As a result, the 2021 season will be the last for Thursday Night Football on FOX. FOX will continue to produce the National Football Conference (NFC) package of Sunday afternoon games with a focus on America's Game of the Week, the most-watched show across television for the last 12 seasons and the most-watched NFL window for the last 20 seasons.

The NFL and Amazon first partnered on Thursday Night Football as part of a tri-cast distribution model during the 2017 season, initially with CBS/NBC and then FOX starting in 2018.

The NFL continues to be the only sports league that delivers all its games – regular season and playoffs – on free, over-the-air television.